Beautiful Lake Cherokee Dockable Waterfront Lots ready to build your lakefront dream home or get away. Lake Cherokee (also known as Lake Isaquenna) is a private lake approximately 300 acres in size at the edge of the Sumter National Forest. Lake Cherokee is the largest of several private lakes in the Oconee mountain region. This lake is located in Tamassee with Walhalla and Seneca being close by. Enjoy mountain and lake activities with an abundance of waterfalls and hiking trails, as well as boating, fishing, and swimming. Residential area has boat ramp.